Ghana House is a small one-room structure with horizontal planks and full dovetail notched corners, associated with the plantation established in 1796 by the remarkable Metoyer family of formerly enslaved people and known since 1885 as Melrose Plantation. It is one of five buildings there dating from the period of African American ownership from 1796 to 1847. In the 1930s, Cammie Henry moved the building to Melrose from the Dominique Metoyer Plantation, two plantations downriver, then added the chimney and used it as a wash house, garden shed, and cabin for guests. Dominique Metoyer was a son of Marie Therese Coin-Coin, an enslaved person, and the French merchant and planter Claude Thomas Pierre Metoyer. The broader Cane River and Isle Brevelle community was a historic Creole center where many Metoyer descendants settled, and Augustin and Louis Metoyer were among the wealthiest people in the United States during the early 19th century.