Jaybird Cave in Perry County, Tennessee, near the Buffalo River northeast of Lobelville, is significant for both local history and ecology. It is traditionally associated with Henri DeLobel, founder of Lobelville, who reportedly used the cave as shelter, tying it to the area's early settlement. Archaeological evidence shows that saltpeter mining also occurred there, reflecting an older pattern of cave use in Tennessee. In more recent times, the cave has served as a roosting site for the endangered little brown bat. Its ecological importance deepened in 2013, when white-nose syndrome was detected there as part of the broader bat conservation crisis in North America.