Central Baptist Church of Jacksonville was organized on September 12, 1906, when 22 charter members met at the home of the Rev. E.G. Musgrove. Two weeks later, a revival led by the noted Baptist preacher George W. Truett brought 32 additions to the congregation. Affiliated with the Baptist General Convention of Texas and the Southern Baptist Convention, the church was named for its central location in Jacksonville and received its charter on May 4, 1909. The congregation first met at 401 South Main in a small white frame building that was sold and moved in 1913 to make room for new construction. In 1919, a devastating fire destroyed the interior of the new building, and the day after the fire the members voted to rebuild without outside aid, achieving that goal within five years. In 1939, the church added the D.B. Lloyd Educational Building for Sunday school classes. It sponsored a variety of outreach programs, including four mission churches; during the Depression Era, the Goodfellows Bible Class helped those in need; and since 1943 the congregation has sponsored Boy Scout Troop 403. In 1951, the congregation built a new sanctuary and formal hall along with educational and office space. In 2003, it relocated to 1909 E. Rusk Street. By the following year, 19 pastors had served the congregation, its membership included more than 2,500 members, and more than 1,600 participated in Sunday school. Though no longer centrally located, the church continues to focus on outreach to the community.