San Antonio's third railroad depot replaced a 1927 facility that burned in 1949. It is the last remaining depot on the Orange Belt Railway, which crossed Pasco County in 1888 to connect the St. Johns River with the Gulf and provided a long-awaited link with northern markets. The Seaboard Coast Line had its last scheduled service here in 1972. The tracks were removed in 1978, dooming the Trilby, San Antonio and Cypress excursion line, which then ran from this station as the Orange Belt Rail Road. Volunteers restored the depot for community use in 1993.