The area that is now Simpson County lay in the extreme southwest portion of the Choctaw Nation’s southern division, part of the Six Towns district, whose chief was Pushmataha. Although some mounds in the county and Choctaw artifacts have been found, there is no definite evidence of Choctaw towns there. The well-known Three-Chopped-Way may have crossed the county’s southwest corner, and an 1824 map of Mississippi shows an old Indian path crossing Simpson County. Through treaties made between 1786 and 1830, the Choctaw Nation progressively ceded its lands to the United States, and the area that is now Simpson County lay in the extreme southeast corner of the land ceded in 1820 by the Treaty of Doak’s Stand. After that treaty, the last Choctaw encampment in Simpson County was south of Weathersby. The area was settled in the early 1800s by the Hayes and Weathersby families, and a town grew there with stores, mills, a hotel, a church, and a school. Its first post office was established in 1897, and the town was incorporated in 1901. Today Weathersby has been incorporated into Mendenhall, but it remains a distinct community centered around the historic Weathersby Baptist Church on U.S. Highway 49.