Settled around 1724 by Everhard Ream and founded as a town by his son Tobias Ream in 1760, originally called Zoar, Reamstown became an important stop near the halfway point on the Lancaster-Reading stage coach line during the 18th and 19th centuries. In 1777, during the Revolutionary War, a field hospital was set up there for wounded soldiers from the Battle of Brandywine, some of whom are buried in the cemetery.