The Kansas City, Mexico, and Orient Railway Company built this depot in 1909-10 as the largest of its depots and as headquarters for its state offices in San Angelo, which had won a bitter contest over Sweetwater to become a major station on Arthur E. Stilwell’s international rail system. Promoted as part of a proposed 1,600-mile route from Kansas City, Missouri, to Topolabampo, Mexico, the rail system was never fully completed. Designed by the KCM&O Engineering Department, with most drawings bearing the name or initials of Albert T. Camfield, the depot is a large two-story rectangular structure with a bell-hipped tile roof, deep overhangs, dormers on the street façade, red brick walls with cast stone detailing, a one-story hipped-roof canopy and covered entrance on three sides, and a square projecting tower with pyramidal roof on the track side for the dispatcher. Its first floor contained segregated waiting rooms, a ticket office, baggage handling area, gentlemen’s smoking room, and ladies’ parlor, while the second floor was devoted to offices. After early struggles, the company benefited from west Texas oil discoveries in the early 1920s, which brought higher profits and capital improvements, before the Atchison, Topeka and Santa Fe Railway Company purchased the KCM&O in 1928. In 1989, after Santa Fe announced plans to raze the freight and passenger depots, citizens successfully campaigned to preserve and rehabilitate the buildings as a senior services center and railroad museum.