The production of pre-packed pharmaceutical products, known as patent or proprietary medicines, flourished in the late 19th century. Dr. Burney James Kendall (1845-1922) opened a drug store in 1870 and soon sold his own remedies. In 1880, the Dr. B.J. Kendall Co. began manufacturing Spavin Cure for horse and human use in Enosburg Falls. Other local patent medicine companies included the Dr. G.S. Greene Co., Kimball Brothers Co. and Dr. F.S. Hutchinson & Co. The industry aggressively marketed cure-alls, but their secret formulas often contained dangerous amounts of alcohol and narcotics, and many were ineffective or addictive. Although self-medication continued, the Pure Food and Drug Act introduced regulations in 1906.