Glazier was founded in 1887 when the Panhandle and Santa Fe Railway reached the site. North of the Canadian River, it became an ideal shipping point for area cattle even when flooding made the river impassable. A post office was established there in 1906. In 1916, a fire that started in a feed mill virtually destroyed the town's business district. A tornado claimed twelve lives in 1947, dealing another major blow to the small town. The earliest known burials in Glazier Cemetery were made in 1906, and the Glazier Cemetery Association purchased 2.4 acres from J.F. Johnson in 1910 for twenty-five dollars.