Mesopotamia Village District was listed in the National Register of Historic Places on December 24, 1974. Many consider it to be the most unspoiled nineteenth century central green type of village in northeastern Ohio. The district includes houses, commercial buildings, a town hall, churches, and a cemetery surrounding a 1600-foot-long public green, and these structures represent Greek Revival, Gothic Revival, Queen Anne, Italianate, and vernacular architectural styles constructed between 1820 and 1902. One of the oldest buildings in the district is a colonnaded Greek Revival commercial building at the southwest end of the green, built in the 1820s for early resident Isaac Clark and later operated as a store by F.G. Peck; over the ensuing centuries it also served as a barber shop, post office, and undertakers. An 1867 Civil War monument rises at the south end of Mesopotamia's public green; sculpted by Howard Briden and Walter Supple, the marble column honors the 95 men who served in the war and the 17 who never returned. Behind the monument stands a gabled brick Town Hall erected in 1902. North along Phelps Creek Road are three early churches: a Universalist Church from 1846, a Methodist Church from the 1830s with 1865-1870 additions, and a Congregationalist Church from 1843. The Universalist building has served as town hall, grange, and museum. Fairview Cemetery, behind the churches, has been the burial ground for Mesopotamia residents since 1818. The public green, lined on both sides with examples of mostly pre-Civil War frame houses, anchors a rare survival of an early Ohio village.