The Unitarian Universalist Church of Tarpon Springs traces its beginnings to 1885, when Rev. Henry D. L. Webster, Anson P. K. Safford, and John K. Cheyney organized the Universalist Church of the Good Shephard, one of the earliest churches in Tarpon Springs. A wood church was built on East Tarpon and Safford Avenues, but after that building was destroyed in a disastrous town fire in 1908, the congregation relocated and built a block church in the Romanesque Revival style constructed by G. E. Noblit. In 1918, a hurricane blew out three windows, and they were replaced by three panels especially painted by artist George Inness, Jr., the first of twelve Inness Jr. paintings displayed in the church. In 1961, the church became the Unitarian Universalist Church of Tarpon Springs. Over the years, modifications and additions changed the building's appearance until sinkhole damage in 2013 created the opportunity to restore the original building and properly display the paintings, and after six years of extensive work, the church formally reopened in September 2019.