Guadalupe Canyon is a canyon and valley in the southern Peloncillo Mountains along the borderlands of New Mexico, Arizona, and Sonora, where its stream flows south from Guadalupe Mountain into Mexico to join the San Bernardino River. It figured in regional history as a route used by the Mormon Battalion in 1846 and as the site of the 1881 Guadalupe Canyon Massacre. The canyon is also a vital cross-border wildlife corridor, with riparian habitat supporting diverse trees and birds and providing movement habitat for species including Mexican gray wolves, jaguars, black bears, mountain lions, ocelots, and white-nosed coatis. In 2020, border wall construction blasted parts of its sides and threatened animal passage.