Santillane is one of Botetourt County’s most distinguished properties. The Greek Revival house sits on a tract of land originally owned by Colonel George Hancock, a member of the United States Congress from 1793-1797. In 1808 Hancock’s daughter, Judith, married General William Clark. Clark served from 1803 to 1806 as a leader of Thomas Jefferson’s famous Lewis and Clark expedition, which was instrumental in opening the West for American settlement.