Constructed in 1850 by John Remaley, whose grandfather Ambrose was an original settler to the area, this building was first called Remaley House after receiving a liquor license in 1851 and was later known as The Slatington Hotel. Edward B. Neff purchased the business in 1869 and operated the hotel for 40 years. Neff was a descendant of Ulich Neff, patriarch of the local Neff families who emigrated from Switzerland. The business included a hotel, livery, and a barroom in the basement. The Neff House remained Slatington's oldest licensed barroom until operations ceased in 1989, and it continues in use as a hotel and rooming house.