Monte Sano Mountain rises east of Huntsville, Alabama, above the Tennessee Valley with a flat summit that helped give it fame as a health refuge in the late nineteenth century. Named by Dr. Thomas Fern during outbreaks of yellow fever, malaria, and cholera, it drew visitors seeking cooler air, springs, and sanitary surroundings. That reputation led to the 1886 Hotel Monte Sano and, two years later, a railway that briefly improved access before failing. As medical knowledge advanced, the resort era ended by 1900. The mountain is also significant for its geology, fossils, and protected natural lands, including Monte Sano State Park and the Monte Sano Nature Preserve.