Little River was the home of Creek Chief William Weatherford, also known as War Chief Red Eagle. The area was the site of much discussion and debate that brought the Creeks into the War of 1812 and the Creek Civil War of 1813-1814. These events weighed heavily in the land forfeiture in the Treaty of Fort Jackson (Toulouse) in 1814. Weatherford surrendered to Andrew Jackson, ceding away the largest single tract of land in Alabama. This treaty set the stage for the forced Creek removal, known as the Trail of Tears, in the 1830s. Alabama remains home to many Creek Indians today, including the Poarch Band of Creek Indians reservation in Escambia County.