Mission Los Santos Ángeles de Guevavi began in 1691 as a Jesuit mission founded by Eusebio Kino and Juan María de Salvatierra at an existing Sobaipuri, or O'odham, settlement in southern Arizona. It became an important frontier center and later supervised nearby missions, despite long periods without a resident priest. The surviving ruins largely date to a larger church begun in 1751, later damaged in the Pima Revolt and renovated in 1754. After repeated Apache attacks and a transfer of district headquarters to Tumacácori, the site was abandoned by 1776. Archaeology has revealed both mission remains and the earlier indigenous settlement, preserving a key place in Sonoran borderlands history.