On November 5, 1909, a group of worshipers gathered in the Congregational Church on the corner of Saint Joseph and Evergreen Streets and organized the Second Saint Siloam Missionary Baptist Church. On June 10, 1910, the congregation moved into this building at the corner of East and North East Streets. The congregation credits Reverend William Franklin, the church's first pastor, with visualizing the church's unique architectural design, which is based on the cruciform plan and features a three-sided balcony, cathedral ceilings and a bell tower. The first deacons were Peter Blankenship, P. J. Johnson, Johnny Robbins, Alex Allen and Alex Hamilton. The first trustees were S. W. Mills, Chairman; R. T. Thompson, Secretary; Jim Dean, L. L. Ingraham, Charlie Smith, Josh Feagan, J. H. Mills and Walker Dacus. The Alabama Historical Commission included the Second Saint Siloam Missionary Baptist Church in the Alabama Register of Landmarks and Heritage in April 2010.