Brandywine Mansion, a small house in the Lukens National Historic District, is the district's oldest structure. Its original east section, closer to the road, dates to the mid 1700s, and a larger west section was added around 1788, shortly after the property was sold to Moses Coates. President George Washington is believed to have stopped there in 1794 on his way to Philadelphia after quelling the Whiskey Rebellion in western Pennsylvania. In 1810, Moses Coates sold the house and 110.5 acres to Jesse Kersey and ironmaster Isaac Pennock. Pennock converted the farm's sawmill into a rolling mill, and his Brandywine Iron Works & Nail Factory became the beginning of Lukens Steel Company. In 1816, Pennock's daughter Rebecca and her husband, Dr. Charles Lukens, moved into Brandywine Mansion, and by 1818 they had begun restructuring the mill to roll plate iron. After Charles Lukens died in 1825, Rebecca took over management of the mill and is credited as America's first and most prominent female industrialist. She continued to live in Brandywine Mansion until her death in 1854.