Jeremiah Jenks and John L. Woods built the Cadillac House hotel in the Italianate style in 1860, and it opened on July 4 of that year with songs by the Lexington Glee Club, a parade, dinner, and dancing. Named for Antoine De La Mothe Cadillac, the founder of Fort Pontchartrain, later Detroit, it first served people in Lexington connected to the fishing and lumber industries. By 1884 it was the largest hotel in Lexington, and in 1893 it had thirty rooms. As Lexington's fishing and lumber industries declined near the start of the twentieth century, the Cadillac House became a resort hotel. Business prospered in the 1920s as automobiles and new roads brought more summer vacationers. The hotel portion had closed by the 1960s, but the restaurant continued serving customers until 2016. A historic rehabilitation in 2018 replicated the nineteenth-century brick chimneys, front porch, and cupola, and in 2019 the project received two state historic preservation awards.