The Koffel Building was constructed in 1891 by H.R. Koffel to house Koffel's Drug Store, also known as Modern Drugs, and Farmers State Bank in the Courthouse Historic District on Main Street in downtown Knox, Indiana. Its two ground-floor units were divided by a brick partition wall down the middle of the building, allowing the two upper-floor units to share a common staircase. This two-part commercial block was the most common type of construction for small and medium-sized commercial buildings during this time. In 1892, brick streets were laid and wooden sidewalks were replaced with concrete, and city water became available in 1908. The building was razed in 2013, and six other two-part commercial block buildings were constructed in downtown Knox.