Dedicated on December 27, 1900, the Big Four Depot served as division headquarters for the Cleveland, Chicago, Cincinnati, and St. Louis railroad, commonly called the Big Four. Peak passenger usage came during and after World War I, when 32 trains stopped there daily. Railway Express serviced as many as 20 trains a day into the 1950s, and Galion became a whistle stop for presidential campaigns, with speeches from the train platform by candidates such as Al Smith in 1928, Franklin D. Roosevelt in 1932, and Dwight D. Eisenhower and Richard Nixon in 1952. In 1929 the New York Central acquired the Big Four and moved the division headquarters west to Bellefontaine in Logan County. The ticket office remained open until 1964, but all railroad offices closed in 1969. The depot was listed on the National Register of Historic Places in 1974.