First Presbyterian Church of Memphis was established in 1890 under the leadership of the Rev. A. W. Rogers and began with thirteen members. Its second sanctuary was completed in 1911 during the pastorate of the Rev. Dr. R. T. Caldwell. Built by member J. S. Cobb, the building features neoclassical revival detailing in its arched windows and domed roof, and its interior furnishings include a large pipe organ originally powered by water pressure.