Jersey Shore is a borough in Lycoming County, Pennsylvania, United States. It is on the West Branch Susquehanna River, 15 mi west by south of Williamsport. It is part of the Williamsport, Pennsylvania Metropolitan Statistical Area. In the past, Jersey Shore held farms, railroad shops, cigar factories, a foundry, and a large silk mill. The population was 4,158 at the 2020 census.

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