This building became possible after the city acquired four lots from William Morton in 1920. In 1922, Okmulgee's Black citizens secured $25,000 in donations from Federated Clubs and their own leading citizens to complete the funding for construction of the first “Colored hospital” opened in the state of Oklahoma. After the building was completed, the Black community raised additional funds to equip it and make it operational. In 1924, Black citizens formed the Colored Hospital Association, and the hospital opened that year with 18-20 beds and living quarters for a staff of six to seven nurses. The building was estimated to cost $50,000. In 1936, it was leased for three years to Dr. J.H. Burt. The hospital provided important medical services and care, but it also stood as a symbol of segregation before the Civil Rights movement. When Okmulgee integrated a number of health facilities in 1957, the Okmulgee Colored Hospital closed. In 1984, the building was listed in the National Register of Historic Places.