The Mill-Pine neighborhood grew from the need for housing near the railroad after the Oregon-California railroad line was completed from Portland to Roseburg in 1872 and on to Ashland in 1884. Aaron Rose, the community's founder, then began developing this neighborhood adjacent to the railroad property. The first, second, third, and fourth southern additions to the City of Roseburg were platted between 1887 and 1894. A large proportion of Mill-Pine residents were associated with the railroad, working in jobs ranging from wiper to engineer and servicing the many trains that passed through Roseburg each day. Other residents worked in various occupations in a town made prosperous by the coming of the railroad. In 1927, the railroad regional division point moved north, railroad employment in Roseburg dwindled, and the neighborhood has remained largely unchanged since that time.