Wesley and Mary Lowe farmed a variety of crops in the Anona region, a community that grew up around Wesley's father's homestead, and as their family business grew they replaced a smaller barn with this one by 1911. Wesley's son Sumner recalled handing wood up from the little barn to his father as the family salvaged the best lumber for the new building. The Lowes stored hay in the barn and kept horses and cows there, and Sumner remembered that his father kept a horse-drawn buggy and wagon in it before the family purchased its first automobile. Wesley Lowe used rot-resistant cypress lumber as the foundation for the structure. At one time the barn also served as a garage, with farm animals sharing space with the family's Model T Ford as they once had with the family buggy. In the late 1940s Paul Randolph purchased the Lowe property for cattle and horses at Randolph Farms, and as late as the 1960s his cowhands herded cattle from the barn across Indian Rocks Road to nearby pastures. Randolph later added stables and pens on each side of the barn. Barns like this were uncommon on the Pinellas landscape because cattle were permitted to range freely in Florida until 1949, and other agriculture such as citrus did not require this kind of storage. The barn's original site is now part of the Randolph Farms Condominiums.