The W. Henry Lewis House was built in 1901 by W. Henry Lewis, a pioneer cattleman, financier, and philanthropist born in Thomasville, Georgia, in 1860 who came to Florida as a young man. He married Sallie Singletary in 1887, and six of their children lived to adulthood: Asa, James, Lettie, Martha, Anna Belle, and Virginia. Lewis became a successful businessman in cattle-raising, citrus, and real estate, and with "Doc" Lightsey he was a leading cattleman in Polk County, owning thousands of cattle and thousands of acres along the Kissimmee River. He also held interests in several Polk County banks, helped organize the First State Bank of Fort Meade, and served as its president. An advocate of good roads, he was one of three trustees of a million-dollar road bond issue in Polk County, the first of its kind in Florida. He chose Fort Meade, the center of his cattle enterprises, as his home. After his death, his daughter Virginia and her husband Carlton Marsh purchased the house, and Virginia lived there until her death in 1998. The two-story house combines Colonial Revival and Queen Anne architectural elements and was listed on the National Register of Historic Places in 2012.