Sinepuxent or Sinepuxent Town was a village in Worcester County, Maryland, located on Sinepuxent Neck across Sinepuxent Bay from the barrier island of Assateague. The village was destroyed by a hurricane in 1818 and never rebuilt. Its location arose in large part from its convenience to ocean-going ships: an inlet—Sinepuxent Inlet—allowed access through Assateague Island from the Atlantic Ocean to Sinepuxent Bay, until it was closed by the same hurricane that destroyed the village.